Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia

C/EBPα is a key transcription factor regulating myeloid differentiation and leukemogenesis. The Trib1-COP1 complex is an E3 ubiquitin ligase that targets C/EBPα for degradation, and its overexpression specifically induces acute myeloid leukemia (AML). Here we show that myeloid leukemia factor 1 (MLF...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Nakamae, Ikuko, Kato, Jun-ya, Yokoyama, Takashi, Ito, Hidenori, Yoneda-Kato, Noriko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728337/
https://ncbi.nlm.nih.gov/pubmed/29296815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007054
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