A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking

Polarization of node cells along the anterior-posterior axis of mouse embryos is responsible for left-right symmetry breaking. How node cells become polarized has remained unknown, however. Wnt5a and Wnt5b are expressed posteriorly relative to the node, whereas genes for Sfrp inhibitors of Wnt signa...

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Udgivet i:Dev Cell
Main Authors: Minegishi, Katsura, Hashimoto, Masakazu, Ajima, Rieko, Takaoka, Katsuyoshi, Shinohara, Kyosuke, Ikawa, Yayoi, Nishimura, Hiromi, McMahon, Andrew P., Willert, Karl, Okada, Yasushi, Sasaki, Hiroshi, Shi, Dongbo, Fujimori, Toshihiko, Ohtsuka, Toshihisa, Igarashi, Yasunobu, Yamaguchi, Terry P., Shimono, Akihiko, Shiratori, Hidetaka, Hamada, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7974384/
https://ncbi.nlm.nih.gov/pubmed/28292423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.02.010
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