Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Molecular left-right (L-R) asymmetry is established at the node of the mouse embryo as a result of the sensing of a leftward fluid flow by immotile cilia of perinodal crown cells and the consequent degradation of Dand5 mRNA on the left side. We here examined how the fluid flow induces Dand5 mRNA dec...

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Vydáno v:Nat Commun
Hlavní autoři: Minegishi, Katsura, Rothé, Benjamin, Komatsu, Kaoru R., Ono, Hiroki, Ikawa, Yayoi, Nishimura, Hiromi, Katoh, Takanobu A., Kajikawa, Eriko, Sai, Xiaorei, Miyashita, Emi, Takaoka, Katsuyoshi, Bando, Kana, Kiyonari, Hiroshi, Yamamoto, Tadashi, Saito, Hirohide, Constam, Daniel B., Hamada, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249388/
https://ncbi.nlm.nih.gov/pubmed/34210974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24295-2
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