Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Molecular left-right (L-R) asymmetry is established at the node of the mouse embryo as a result of the sensing of a leftward fluid flow by immotile cilia of perinodal crown cells and the consequent degradation of Dand5 mRNA on the left side. We here examined how the fluid flow induces Dand5 mRNA dec...

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Pubblicato in:Nat Commun
Autori principali: Minegishi, Katsura, Rothé, Benjamin, Komatsu, Kaoru R., Ono, Hiroki, Ikawa, Yayoi, Nishimura, Hiromi, Katoh, Takanobu A., Kajikawa, Eriko, Sai, Xiaorei, Miyashita, Emi, Takaoka, Katsuyoshi, Bando, Kana, Kiyonari, Hiroshi, Yamamoto, Tadashi, Saito, Hirohide, Constam, Daniel B., Hamada, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249388/
https://ncbi.nlm.nih.gov/pubmed/34210974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24295-2
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