Solid state NMR assignments of a human λ-III immunoglobulin light chain amyloid fibril

The aggregation of antibody light chains is linked to systemic light chain (AL) amyloidosis, a disease where amyloid deposits frequently affect the heart and the kidney. We here investigate fibrils from the λ-III FOR005 light chain (LC), which is derived from an AL-patient with severe cardiac involv...

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Bibliographic Details
Published in:Biomol NMR Assign
Main Authors: Pradhan, Tejaswini, Annamalai, Karthikeyan, Sarkar, Riddhiman, Hegenbart, Ute, Schönland, Stefan, Fändrich, Marcus, Reif, Bernd
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973639/
https://ncbi.nlm.nih.gov/pubmed/32946005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12104-020-09975-2
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