Mapping the Binding Interface of PET Tracer Molecules and Alzheimer Disease Aβ Fibrils by Using MAS Solid‐State NMR Spectroscopy

Positron emission tomography (PET) tracer molecules like thioflavin T specifically recognize amyloid deposition in brain tissue by selective binding to hydrophobic or aromatic surface grooves on the β‐sheet surface along the fibril axis. The molecular basis of this interaction is, however, not well...

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Publicado en:Chembiochem
Main Authors: Niu, Zheng, Sarkar, Riddhiman, Aichler, Michaela, Wester, Hans‐Jürgen, Yousefi, Behrooz Hooshyar, Reif, Bernd
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496087/
https://ncbi.nlm.nih.gov/pubmed/32291951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000143
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