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Mapping the Binding Interface of PET Tracer Molecules and Alzheimer Disease Aβ Fibrils by Using MAS Solid‐State NMR Spectroscopy
Positron emission tomography (PET) tracer molecules like thioflavin T specifically recognize amyloid deposition in brain tissue by selective binding to hydrophobic or aromatic surface grooves on the β‐sheet surface along the fibril axis. The molecular basis of this interaction is, however, not well...
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| Publicado no: | Chembiochem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7496087/ https://ncbi.nlm.nih.gov/pubmed/32291951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000143 |
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