Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue

Gene therapeutic approaches to aortic diseases require efficient vectors and delivery systems for transduction of endothelial cells (ECs) and smooth muscle cells (SMCs). Here, we developed a novel strategy to efficiently deliver a previously described vascular-specific adeno-associated viral (AAV) v...

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Publicado en:Mol Ther Methods Clin Dev
Autores principales: Remes, Anca, Basha, Dima Ibrahim, Puehler, Thomas, Borowski, Christopher, Hille, Susanne, Kummer, Laura, Wagner, Andreas H., Hecker, Markus, Soethoff, Jasmin, Lutter, Georg, Frank, Derk, Arif, Rawa, Frey, Norbert, Zaradzki, Marcin, Müller, Oliver J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973147/
https://ncbi.nlm.nih.gov/pubmed/33768132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.02.017
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