Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products and for countless gene transfer vectors derived from natural or synthetic viral isolates that are under intense preclinical evaluation. Here, we report a versatile pipeline that enables the direct side-by-side...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Weinmann, Jonas, Weis, Sabrina, Sippel, Josefine, Tulalamba, Warut, Remes, Anca, El Andari, Jihad, Herrmann, Anne-Kathrin, Pham, Quang H., Borowski, Christopher, Hille, Susanne, Schönberger, Tanja, Frey, Norbert, Lenter, Martin, VandenDriessche, Thierry, Müller, Oliver J., Chuah, Marinee K., Lamla, Thorsten, Grimm, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595228/
https://ncbi.nlm.nih.gov/pubmed/33116134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19230-w
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