Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double-strand break repair

We have previously shown that the tyrosine kinase inhibitors (TKIs) dasatinib and imatinib can protect salivary glands from irradiation (IR) damage without impacting tumor therapy. However, how they induce this protection is unknown. Here we show that TKIs mediate radioprotection by increasing the r...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Affandi, Trisiani, Ohm, Angela M., Gaillard, Dany, Haas, Ami, Reyland, Mary E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973138/
https://ncbi.nlm.nih.gov/pubmed/33571522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100401
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