Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double-strand break repair

We have previously shown that the tyrosine kinase inhibitors (TKIs) dasatinib and imatinib can protect salivary glands from irradiation (IR) damage without impacting tumor therapy. However, how they induce this protection is unknown. Here we show that TKIs mediate radioprotection by increasing the r...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Affandi, Trisiani, Ohm, Angela M., Gaillard, Dany, Haas, Ami, Reyland, Mary E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973138/
https://ncbi.nlm.nih.gov/pubmed/33571522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100401
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