Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double-strand break repair

We have previously shown that the tyrosine kinase inhibitors (TKIs) dasatinib and imatinib can protect salivary glands from irradiation (IR) damage without impacting tumor therapy. However, how they induce this protection is unknown. Here we show that TKIs mediate radioprotection by increasing the r...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Affandi, Trisiani, Ohm, Angela M., Gaillard, Dany, Haas, Ami, Reyland, Mary E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973138/
https://ncbi.nlm.nih.gov/pubmed/33571522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100401
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