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EGF receptor and PKCδ kinase activate DNA damage–induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases
DNA damage–mediated activation of extracellular signal–regulated kinase (ERK) can regulate both cell survival and cell death. We show here that ERK activation in this context is biphasic and that early and late activation events are mediated by distinct upstream signals that drive cell survival and...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6433046/ https://ncbi.nlm.nih.gov/pubmed/30679314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006944 |
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