EGF receptor and PKCδ kinase activate DNA damage–induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases

DNA damage–mediated activation of extracellular signal–regulated kinase (ERK) can regulate both cell survival and cell death. We show here that ERK activation in this context is biphasic and that early and late activation events are mediated by distinct upstream signals that drive cell survival and...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Ohm, Angela M., Affandi, Trisiani, Reyland, Mary E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433046/
https://ncbi.nlm.nih.gov/pubmed/30679314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006944
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