Endothelial mTOR maintains hematopoiesis during aging

Aging leads to a decline in hematopoietic stem and progenitor cell (HSPC) function. We recently discovered that aging of bone marrow endothelial cells (BMECs) leads to an altered crosstalk between the BMEC niche and HSPCs, which instructs young HSPCs to behave as aged HSPCs. Here, we demonstrate agi...

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Bibliografiska uppgifter
I publikationen:J Exp Med
Huvudupphovsmän: Ramalingam, Pradeep, Poulos, Michael G., Gutkin, Michael C., Katsnelson, Lizabeth, Freire, Ana G., Lazzari, Elisa, Butler, Jason M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Rockefeller University Press 2020
Ämnen:
Brief Definitive Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971143/
https://ncbi.nlm.nih.gov/pubmed/32289154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191212
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