Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

Inflammatory signals arising from the microenvironment have emerged as critical regulators of hematopoietic stem cell (HSC) function during diverse processes including embryonic development, infectious diseases, and myelosuppressive injuries caused by irradiation and chemotherapy. However, the contr...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Ramalingam, Pradeep, Poulos, Michael G., Lazzari, Elisa, Gutkin, Michael C., Lopez, David, Kloss, Christopher C., Crowley, Michael J., Katsnelson, Lizabeth, Freire, Ana G., Greenblatt, Matthew B., Park, Christopher Y., Butler, Jason M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997369/
https://ncbi.nlm.nih.gov/pubmed/32015345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14478-8
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