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Endothelial mTOR maintains hematopoiesis during aging
Aging leads to a decline in hematopoietic stem and progenitor cell (HSPC) function. We recently discovered that aging of bone marrow endothelial cells (BMECs) leads to an altered crosstalk between the BMEC niche and HSPCs, which instructs young HSPCs to behave as aged HSPCs. Here, we demonstrate agi...
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| Publicado en: | J Exp Med |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Rockefeller University Press
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7971143/ https://ncbi.nlm.nih.gov/pubmed/32289154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191212 |
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