Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

We have generated mouse models of malignant mesothelioma (MM) based upon disruption of the Bap1, Nf2, and Cdkn2ab tumor suppressor loci in various combinations as also frequently observed in human MM. Inactivation of all three loci in the mesothelial lining of the thoracic cavity leads to a highly a...

詳細記述

保存先:
書誌詳細
出版年:J Exp Med
主要な著者: Badhai, Jitendra, Pandey, Gaurav Kumar, Song, Ji-Ying, Krijgsman, Oscar, Bhaskaran, Rajith, Chandrasekaran, Gayathri, Kwon, Min-chul, Bombardelli, Lorenzo, Monkhorst, Kim, Grasso, Cristoforo, Zevenhoven, John, van der Vliet, Jan, Cozijnsen, Miranda, Krimpenfort, Paul, Peeper, Daniel, van Lohuizen, Maarten, Berns, Anton
フォーマット: Artigo
言語:Inglês
出版事項: Rockefeller University Press 2020
主題:
Brief Definitive Report
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971132/
https://ncbi.nlm.nih.gov/pubmed/32271879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191257
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