Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer

Small-cell lung cancer is the most aggressive type of lung cancer, characterized by a remarkable response to chemotherapy followed by development of resistance. Here, we describe SCLC subtypes in Mycl- and Nfib-driven GEMM that include CDH1-high peripheral primary tumor lesions and CDH1-negative, ag...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Böttger, Franziska, Semenova, Ekaterina A., Song, Ji-Ying, Ferone, Giustina, van der Vliet, Jan, Cozijnsen, Miranda, Bhaskaran, Rajith, Bombardelli, Lorenzo, Piersma, Sander R., Pham, Thang V., Jimenez, Connie R., Berns, Anton
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581744/
https://ncbi.nlm.nih.gov/pubmed/31189116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.057
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