FGFR1 Oncogenic Activation Reveals an Alternative Cell of Origin of SCLC in Rb1/p53 Mice

Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified in human small-cell lung cancer (SCLC), but its contribution to SCLC and other lung tumors has remained elusive. Here, we assess the tumorigenic capacity of constitutive-active FGFR1 (FGFR1(K656E)) with concomitant RB and P53 deplet...

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Publicat a:Cell Rep
Autors principals: Ferone, Giustina, Song, Ji-Ying, Krijgsman, Oscar, van der Vliet, Jan, Cozijnsen, Miranda, Semenova, Ekaterina A., Adams, David J., Peeper, Daniel, Berns, Anton
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7090386/
https://ncbi.nlm.nih.gov/pubmed/32187553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.052
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