Inhibition of the replication stress response is a synthetic vulnerability in SCLC that acts synergistically in combination with cisplatin

Small cell lung cancer (SCLC) is generally regarded as very difficult to treat, mostly due to the development of metastases early in the disease and a quick relapse with resistant disease. SCLC patients initially show a good response to treatment with the DNA damaging agents cisplatin and etoposide....

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Nagel, Remco, Avelar, Ana Teresa, Aben, Nanne, Proost, Natalie, van de Ven, Marieke, van der Vliet, Jan, Cozijnsen, Miranda, de Vries, Hilda, Wessels, Lodewyk F.A., Berns, Anton
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451635/
https://ncbi.nlm.nih.gov/pubmed/30872379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0972
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