A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis

Cdkn2ab knockout mice, generated from 129P2 ES cells develop skin carcinomas. Here we show that the incidence of these carcinomas drops gradually in the course of backcrossing to the FVB/N background. Microsatellite analyses indicate that this cancer phenotype is linked to a 20 Mb region of 129P2 ch...

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Publicat a:Nat Commun
Autors principals: Krimpenfort, Paul, Snoek, Margriet, Lambooij, Jan-Paul, Song, Ji-Ying, van der Weide, Robin, Bhaskaran, Rajith, Teunissen, Hans, Adams, David J., de Wit, Elzo, Berns, Anton
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441055/
https://ncbi.nlm.nih.gov/pubmed/30926782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09321-8
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