A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis

Cdkn2ab knockout mice, generated from 129P2 ES cells develop skin carcinomas. Here we show that the incidence of these carcinomas drops gradually in the course of backcrossing to the FVB/N background. Microsatellite analyses indicate that this cancer phenotype is linked to a 20 Mb region of 129P2 ch...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Krimpenfort, Paul, Snoek, Margriet, Lambooij, Jan-Paul, Song, Ji-Ying, van der Weide, Robin, Bhaskaran, Rajith, Teunissen, Hans, Adams, David J., de Wit, Elzo, Berns, Anton
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441055/
https://ncbi.nlm.nih.gov/pubmed/30926782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09321-8
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