Difference of binding modes among three ligands to a receptor mSin3B corresponding to their inhibitory activities

A preceding experiment suggested that a compound, which inhibits binding of the REST/NRSF segment to the cleft of a receptor protein mSin3B, can be a potential drug candidate to ameliorate many neuropathies. We have recently developed an enhanced conformational sampling method, genetic-algorithm-gui...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Hayami, Tomonori, Kamiya, Narutoshi, Kasahara, Kota, Kawabata, Takeshi, Kurita, Jun-ichi, Fukunishi, Yoshifumi, Nishimura, Yoshifumi, Nakamura, Haruki, Higo, Junichi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971087/
https://ncbi.nlm.nih.gov/pubmed/33731831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85612-9
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