Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis

Genome-wide association studies for calcific aortic valve stenosis (CAVS) previously reported strong signal for noncoding variants at 1p21.2. Previous study using Mendelian randomization suggested that the locus controls the expression of PALMD encoding Palmdelphin (PALMD). However, the molecular re...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:iScience
Main Authors: Chignon, Arnaud, Rosa, Mickael, Boulanger, Marie-Chloé, Argaud, Déborah, Devillers, Romain, Bon-Baret, Valentin, Mkannez, Ghada, Li, Zhonglin, Rufiange, Anne, Gaudreault, Nathalie, Gosselin, David, Thériault, Sébastien, Bossé, Yohan, Mathieu, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970363/
https://ncbi.nlm.nih.gov/pubmed/33748722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102241
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados