Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis

Genome-wide association studies for calcific aortic valve stenosis (CAVS) previously reported strong signal for noncoding variants at 1p21.2. Previous study using Mendelian randomization suggested that the locus controls the expression of PALMD encoding Palmdelphin (PALMD). However, the molecular re...

詳細記述

保存先:
書誌詳細
出版年:iScience
主要な著者: Chignon, Arnaud, Rosa, Mickael, Boulanger, Marie-Chloé, Argaud, Déborah, Devillers, Romain, Bon-Baret, Valentin, Mkannez, Ghada, Li, Zhonglin, Rufiange, Anne, Gaudreault, Nathalie, Gosselin, David, Thériault, Sébastien, Bossé, Yohan, Mathieu, Patrick
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970363/
https://ncbi.nlm.nih.gov/pubmed/33748722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102241
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