Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis

Genome-wide association studies for calcific aortic valve stenosis (CAVS) previously reported strong signal for noncoding variants at 1p21.2. Previous study using Mendelian randomization suggested that the locus controls the expression of PALMD encoding Palmdelphin (PALMD). However, the molecular re...

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Vydáno v:iScience
Hlavní autoři: Chignon, Arnaud, Rosa, Mickael, Boulanger, Marie-Chloé, Argaud, Déborah, Devillers, Romain, Bon-Baret, Valentin, Mkannez, Ghada, Li, Zhonglin, Rufiange, Anne, Gaudreault, Nathalie, Gosselin, David, Thériault, Sébastien, Bossé, Yohan, Mathieu, Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970363/
https://ncbi.nlm.nih.gov/pubmed/33748722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102241
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