Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence

BACKGROUND: In multiple sclerosis loss of myelin and oligodendrocytes impairs saltatory signal transduction and leads to neuronal loss and functional deficits. Limited capacity of oligodendroglial precursor cells to differentiate into mature cells is the main reason for inefficient myelin repair in...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Manousi, Anastasia, Göttle, Peter, Reiche, Laura, Cui, Qiao-Ling, Healy, Luke M., Akkermann, Rainer, Gruchot, Joel, Schira-Heinen, Jessica, Antel, Jack P., Hartung, Hans-Peter, Küry, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970057/
https://ncbi.nlm.nih.gov/pubmed/33714029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103276
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