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Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence

BACKGROUND: In multiple sclerosis loss of myelin and oligodendrocytes impairs saltatory signal transduction and leads to neuronal loss and functional deficits. Limited capacity of oligodendroglial precursor cells to differentiate into mature cells is the main reason for inefficient myelin repair in...

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Dades bibliogràfiques
Publicat a:EBioMedicine
Autors principals: Manousi, Anastasia, Göttle, Peter, Reiche, Laura, Cui, Qiao-Ling, Healy, Luke M., Akkermann, Rainer, Gruchot, Joel, Schira-Heinen, Jessica, Antel, Jack P., Hartung, Hans-Peter, Küry, Patrick
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970057/
https://ncbi.nlm.nih.gov/pubmed/33714029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103276
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