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Structural mechanism of DNA recognition by the p204 HIN domain

The interferon gamma-inducible protein 16 (IFI16) and its murine homologous protein p204 function in non-sequence specific dsDNA sensing; however, the exact dsDNA recognition mechanisms of IFI16/p204, which harbour two HIN domains, remain unclear. In the present study, we determined crystal structur...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Fan, Xiaojiao, Jiang, Jiansheng, Zhao, Dan, Chen, Feng, Ma, Huan, Smith, Patrick, Unterholzner, Leonie, Xiao, Tsan Sam, Jin, Tengchuan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969034/
https://ncbi.nlm.nih.gov/pubmed/33619523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab076
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