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Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction

NLRP12 is a NOD-like receptor that plays multiple roles in both inflammation and tumorigenesis. Despite the importance, little is known about its mechanism of action at the molecular level. Here, we report the crystal structure of NLRP12 PYD domain at 1.70 Å fused with an maltose-binding protein (MB...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jin, Tengchuan, Huang, Mo, Jiang, Jiansheng, Smith, Patrick, Xiao, Tsan Sam
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749810/
https://ncbi.nlm.nih.gov/pubmed/29293680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190547
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