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Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen

Proteases are among the largest protein families and critical regulators of biochemical processes like apoptosis and blood coagulation. Knowledge of proteases has been expanded by the development of proteomic approaches, however, technology for multiplexed screening of proteases within native enviro...

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Vydáno v:Nat Commun
Hlavní autoři: Uliana, Federico, Vizovišek, Matej, Acquasaliente, Laura, Ciuffa, Rodolfo, Fossati, Andrea, Frommelt, Fabian, Goetze, Sandra, Wollscheid, Bernd, Gstaiger, Matthias, De Filippis, Vincenzo, auf dem Keller, Ulrich, Aebersold, Ruedi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7966775/
https://ncbi.nlm.nih.gov/pubmed/33727531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21754-8
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