Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen

Proteases are among the largest protein families and critical regulators of biochemical processes like apoptosis and blood coagulation. Knowledge of proteases has been expanded by the development of proteomic approaches, however, technology for multiplexed screening of proteases within native enviro...

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Pubblicato in:Nat Commun
Autori principali: Uliana, Federico, Vizovišek, Matej, Acquasaliente, Laura, Ciuffa, Rodolfo, Fossati, Andrea, Frommelt, Fabian, Goetze, Sandra, Wollscheid, Bernd, Gstaiger, Matthias, De Filippis, Vincenzo, auf dem Keller, Ulrich, Aebersold, Ruedi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7966775/
https://ncbi.nlm.nih.gov/pubmed/33727531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21754-8
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