Cleavage Entropy as Quantitative Measure of Protease Specificity

A purely information theory-guided approach to quantitatively characterize protease specificity is established. We calculate an entropy value for each protease subpocket based on sequences of cleaved substrates extracted from the MEROPS database. We compare our results with known subpocket specifici...

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Detaylı Bibliyografya
Asıl Yazarlar: Fuchs, Julian E., von Grafenstein, Susanne, Huber, Roland G., Margreiter, Michael A., Spitzer, Gudrun M., Wallnoefer, Hannes G., Liedl, Klaus R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630115/
https://ncbi.nlm.nih.gov/pubmed/23637583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003007
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