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Cleavage Entropy as Quantitative Measure of Protease Specificity
A purely information theory-guided approach to quantitatively characterize protease specificity is established. We calculate an entropy value for each protease subpocket based on sequences of cleaved substrates extracted from the MEROPS database. We compare our results with known subpocket specifici...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3630115/ https://ncbi.nlm.nih.gov/pubmed/23637583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003007 |
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