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dCas9 regulator to neutralize competition in CRISPRi circuits
CRISPRi-mediated gene regulation allows simultaneous control of many genes. However, highly specific sgRNA-promoter binding is, alone, insufficient to achieve independent transcriptional regulation of multiple targets. Indeed, due to competition for dCas9, the repression ability of one sgRNA changes...
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| I publikationen: | Nat Commun |
|---|---|
| Huvudupphovsmän: | , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group UK
2021
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7966764/ https://ncbi.nlm.nih.gov/pubmed/33727557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21772-6 |
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