A Mechanistic In Vivo/Ex Vivo Pharmacokinetic‐Pharmacodynamic Model of Tenofovir for HIV Prevention

Defining tissue and plasma‐specific prophylactic drug concentrations is central to pre‐exposure prophylaxis product development for sexual transmission of HIV‐1. Pharmacokinetic (PK) data from study RMP‐02/MTN‐006 comparing single dose oral tenofovir disoproxil fumarate with single and multiple dose...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Jayachandran, Priya, Garcia-Cremades, Maria, Vučićević, Katarina, Bumpus, Namandjé N., Anton, Peter, Hendrix, Craig, Savić, Radojka
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7965838/
https://ncbi.nlm.nih.gov/pubmed/33547874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12583
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