A comparison of the location in membranes of curcumin and curcumin-derived bivalent compounds with potential neuroprotective capacity for Alzheimer’s Disease

Curcumin and two bivalent compounds, namely 17MD and 21MO, both obtained by conjugation of curcumin with a steroid molecule that acts as a membrane anchor, were comparatively studied. When incorporated into 1,2-dipalmitoyl-sn-glycero-3-phosphocholine the compounds showed a very limited solubility in...

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Veröffentlicht in:Colloids Surf B Biointerfaces
Hauptverfasser: Ausili, Alessio, Gómez-Murcia, Victoria, Candel, Adela M., Beltrán, Andrea, Torrecillas, Alejandro, He, Liu, Jiang, Yuqi, Zhang, Shijun, Teruel, José A., Gómez-Fernández, Juan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7965246/
https://ncbi.nlm.nih.gov/pubmed/33373844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.colsurfb.2020.111525
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