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Design and characterization of bivalent compounds as potential neuroprotectants for Alzheimer’s disease: Impact of the spacer on biological activity

In our continuing efforts to develop bivalent compounds as potential neuroprotectants for Alzheimer’s disease, a series of bivalent compounds that contain cholesterylamine and an extended spacer were synthesized and biologically characterized. Our results demonstrated that incorporation of a piperaz...

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Bibliografski detalji
Izdano u:Bioorg Med Chem Lett
Glavni autori: He, Liu, Boice, Ashley, Liu, Kai, Yan, Xing, Jiang, Yuqi, Zhang, Shijun
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851865/
https://ncbi.nlm.nih.gov/pubmed/29475586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.02.028
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