Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease

We previously demonstrated that ibrutinib modulates LPS‐induced neuroinflammation in vitro and in vivo, but its effects on the pathology of Alzheimer's disease (AD) and cognitive function have not been investigated. Here, we investigated the effects of ibrutinib in two mouse models of AD. In 5x...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Lee, Hyun‐ju, Jeon, Seong Gak, Kim, Jieun, Kang, Ri Jin, Kim, Seong‐Min, Han, Kyung‐Min, Park, HyunHee, Kim, Ki‐taek, Sung, You Me, Nam, Hye Yeon, Koh, Young Ho, Song, Minseok, Suk, Kyoungho, Hoe, Hyang‐Sook
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7963331/
https://ncbi.nlm.nih.gov/pubmed/33709472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13332
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