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Insights into lysosomal PI(3,5)P(2) homeostasis from a structural- biochemical analysis of the PIKfyve lipid kinase complex.
The phosphoinositide PI(3,5)P(2), generated exclusively by the PIKfyve lipid kinase complex, is key for lysosomal biology. Here we explore how PI(3,5)P(2) levels within cells are regulated. We find the PIKfyve complex comprises 5 copies of the scaffolding protein Vac14, and one copy each of the lipi...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7962480/ https://ncbi.nlm.nih.gov/pubmed/33098764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.003 |
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