In vivo, Pikfyve generates PI(3,5)P(2), which serves as both a signaling lipid and the major precursor for PI5P

Mutations that cause defects in levels of the signaling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P(2)] lead to profound neurodegeneration in mice. Moreover, mutations in human FIG4 predicted to lower PI(3,5)P(2) levels underlie Charcot–Marie–Tooth type 4J neuropathy and are present in sel...

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Detalhes bibliográficos
Main Authors: Zolov, Sergey N., Bridges, Dave, Zhang, Yanling, Lee, Wei-Wei, Riehle, Ellen, Verma, Rakesh, Lenk, Guy M., Converso-Baran, Kimber, Weide, Thomas, Albin, Roger L., Saltiel, Alan R., Meisler, Miriam H., Russell, Mark W., Weisman, Lois S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491506/
https://ncbi.nlm.nih.gov/pubmed/23047693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203106109
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