Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P(2) and PI(5)P

Normal steady-state levels of the signalling lipids PI(3,5)P(2) and PI(5)P require the lipid kinase FAB1/PIKfyve and its regulators, VAC14 and FIG4. Mutations in the PIKfyve/VAC14/FIG4 pathway are associated with Charcot-Marie-Tooth syndrome and amyotrophic lateral sclerosis in humans, and profound...

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Detalhes bibliográficos
Main Authors: Zhang, Yanling, McCartney, Amber J, Zolov, Sergey N, Ferguson, Cole J, Meisler, Miriam H, Sutton, Michael A, Weisman, Lois S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419932/
https://ncbi.nlm.nih.gov/pubmed/22842785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.200
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