VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse

The signalling lipid PI(3,5)P(2) is generated on endosomes and regulates retrograde traffic to the trans-Golgi network. Physiological signals regulate rapid, transient changes in PI(3,5)P(2) levels. Mutations that lower PI(3,5)P(2) cause neurodegeneration in human patients and mice. The function of...

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Bibliografski detalji
Glavni autori: Jin, Natsuko, Chow, Clement Y, Liu, Li, Zolov, Sergey N, Bronson, Roderick, Davisson, Muriel, Petersen, Jason L, Zhang, Yanling, Park, Sujin, Duex, Jason E, Goldowitz, Daniel, Meisler, Miriam H, Weisman, Lois S
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600653/
https://ncbi.nlm.nih.gov/pubmed/19037259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.248
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