Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer’s disease

SORL1 is strongly associated with both sporadic and familial forms of Alzheimer’s disease (AD), but a lack of information about alternatively spliced transcripts currently limits our understanding of the role of SORL1 in AD. Here, we describe a SORL1 transcript (SORL1-38b) characterized by inclusion...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Monti, Giulia, Kjolby, Mads, Jensen, Anne Mette G., Allen, Mariet, Reiche, Juliane, Møller, Peter L., Comaposada-Baró, Raquel, Zolkowski, Bartlomiej E., Vieira, Cármen, Jørgensen, Margarita Melnikova, Holm, Ida E., Valdmanis, Paul N., Wellner, Niels, Vægter, Christian B., Lincoln, Sarah J., Nykjær, Anders, Ertekin-Taner, Nilüfer, Young, Jessica E., Nyegaard, Mette, Andersen, Olav M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962264/
https://ncbi.nlm.nih.gov/pubmed/33726851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01140-7
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