Gene engineered mesenchymal stem cells: greater transgene expression and efficacy with minicircle vs. plasmid DNA vectors in a mouse model of acute lung injury

BACKGROUND: Acute lung injury (ALI) and in its severe form, acute respiratory distress syndrome (ARDS), results in increased pulmonary vascular inflammation and permeability and is a major cause of mortality in many critically ill patients. Although cell-based therapies have shown promise in experim...

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Bibliografiset tiedot
Julkaisussa:Stem Cell Res Ther
Päätekijät: Florian, Maria, Wang, Jia-Pey, Deng, Yupu, Souza-Moreira, Luciana, Stewart, Duncan J., Mei, Shirley H. J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2021
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962085/
https://ncbi.nlm.nih.gov/pubmed/33726829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02245-5
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