Radioprotection In Vitro and In Vivo by Minicircle Plasmid Carrying the Human Manganese Superoxide Dismutase Transgene

Manganese superoxide dismutase plasmid liposomes (MnSOD-PL) confer organ-specific in vivo ionizing irradiation protection. To prepare for potential intravenous clinical trials of systemic MnSOD-PL for radioprotection in humans, plasmid and bacterial sequences were removed and a new minicircle constr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Xichen, Epperly, Michael W., Kay, Mark A., Chen, Zhi-Ying, Dixon, Tracy, Franicola, Darcy, Greenberger, Benjamin A., Komanduri, Paavani, Greenberger, Joel S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2008
Schlagworte:
Scientific Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914206/
https://ncbi.nlm.nih.gov/pubmed/18699723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2007.141
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