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Catalytic Asymmetric and Stereodivergent Oligonucleotide Synthesis
We report the catalytic stereocontrolled synthesis of dinucleotides. Chiral phosphoric acid (CPA) catalysts are demonstrated to control the formation of stereogenic phosphorous centers during phosphoramidite transfer for the first time. Unprecedented levels of diastereodivergence are also demonstrat...
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| Veröffentlicht in: | Science |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7961808/ https://ncbi.nlm.nih.gov/pubmed/33574208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abf4359 |
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