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Catalytic Asymmetric Synthesis of α-Arylpyrrolidines and Benzo-fused Nitrogen Heterocycles

Herein we report a practical two-step synthetic route to α-arylpyrrolidines consisting of Suzuki-Miyaura cross-coupling and enantioselective copper-catalyzed intramolecular hydroamination reactions. The excellent stereoselectivity and broad scope for the transformation of substrates with pharmaceuti...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Dai, Xi-Jie, Engl, Oliver D., León, Thierry, Buchwald, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553474/
https://ncbi.nlm.nih.gov/pubmed/30659729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201814331
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