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Catalytic Asymmetric Total Synthesis of (−)-Actinophyllic Acid

Described herein is a catalytic asymmetric total synthesis of (−)-actinophyllic acid, with the key step being a chiral phosphine-catalyzed [3 + 2] annulation between an imine and an allenoate to form a pyrroline intermediate in 99% yield and 94% ee. The synthesis also features CuI-catalyzed coupling...

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Publicat a:J Am Chem Soc
Autors principals: Cai, Lingchao, Zhang, Kui, Kwon, Ohyun
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920546/
https://ncbi.nlm.nih.gov/pubmed/26910382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b00567
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