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The zinc-binding domain of mammalian prolyl-tRNA synthetase is indispensable for catalytic activity and organism viability

Aminoacyl-tRNA synthetases (AARS) participate in decoding the genome by catalyzing conjugation of amino acids to their cognate tRNAs. During evolution, biochemical and environmental conditions markedly influenced the sequence and structure of the 20 AARSs, revealing adaptations dictating canonical a...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Vasu, Kommireddy, Ramachandiran, Iyappan, Terenzi, Fulvia, Khan, Debjit, China, Arnab, Khan, Krishnendu, Chechi, Aayushi, Baleanu-Gogonea, Camelia, Gogonea, Valentin, Fox, Paul L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7960942/
https://ncbi.nlm.nih.gov/pubmed/33748704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102215
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