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Metabolic origin of the fused aminoacyl-tRNA synthetase, glutamyl-prolyl-tRNA synthetase

About 1 billion years ago, in a single-celled holozoan ancestor of all animals, a gene fusion of two tRNA synthetases formed the bifunctional enzyme, glutamyl-prolyl-tRNA synthetase (EPRS). We propose here that a confluence of metabolic, biochemical, and environmental factors contributed to the spec...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Eswarappa, Sandeep M., Potdar, Alka A., Sahoo, Sarthak, Sankar, Santhosh, Fox, Paul L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295713/
https://ncbi.nlm.nih.gov/pubmed/30309984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004276
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