Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study

BACKGROUND: Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was evidence of subtle neurodegeneration. Here, we u...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Johnson, Eileanoir B., Parker, Christopher S., Scahill, Rachael I., Gregory, Sarah, Papoutsi, Marina, Zeun, Paul, Osborne-Crowley, Katherine, Lowe, Jessica, Nair, Akshay, Estevez-Fraga, Carlos, Fayer, Kate, Rees, Geraint, Zhang, Hui, Tabrizi, Sarah J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7960938/
https://ncbi.nlm.nih.gov/pubmed/33706250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103266
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