Fronto-striatal circuits for cognitive flexibility in far from onset Huntington’s disease: evidence from the Young Adult Study

OBJECTIVES: Cognitive flexibility, which is key for adaptive decision-making, engages prefrontal cortex (PFC)-striatal circuitry and is impaired in both manifest and premanifest Huntington’s disease (pre-HD). The aim of this study was to examine cognitive flexibility in a far from onset pre-HD cohor...

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Pubblicato in:J Neurol Neurosurg Psychiatry
Autori principali: Langley, Christelle, Gregory, Sarah, Osborne-Crowley, Katie, O'Callaghan, Claire, Zeun, Paul, Lowe, Jessica, Johnson, Eileanoir B, Papoutsi, Marina, Scahill, Rachael I, Rees, Geraint, Tabrizi, Sarah J, Robbins, Trevor W, Sahakian, Barbara Jacquelyn
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2021
Soggetti:
Cognition
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841479/
https://ncbi.nlm.nih.gov/pubmed/33130575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2020-324104
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